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10.2174/187152411796011303 Central Nerv

Exendin-4 significantly increased insulin level and phosphorylation of insulin receptor substrate 1 (IRS-1) in rat hippocampus, and could not change the status of tau phosphorylation without insulin in HT22 neurons, suggesting that insulin is required in reduction of tau hyperphosphorylation by GLP-1R agonists (154)

Available from: Kieler H, et al

This means it activates both the GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors

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