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Catalase activity, which can be readily demonstrated in normal liver, is markedly increased in hypertrophic hepatocytes induced by peroxisome proliferators (Greaves 2007)

The biomechanic function, microscopy/immunochemistry, and macroscopy improvement consistently supported each other

Mechanistically, UA enhances mitochondrial -oxidation and potentially activating skeletal muscle adenosine 5-monophosphate-activated protein kinase (AMPK) signaling and upregulating mitochondrial respiratory chain complex activity to exert ergogenic effects

GLP-1 signaling in pancreatic -cells increases insulin secretion in a blood glucose level-dependent manner, leading to decrease of blood glucose levels 3

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doi: 10.3389/fcell.2022.1033645, 67 LannfeltL.BlennowK.ZetterbergH.BatsmanS.AmesD.HarrisonJ.et al