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Key pathway members are the GTPase RAP1, its appropriate guanine nucleotide exchange factors, talin, kindlin 3 (also known as FERMT3) and phosphatidylinositol-4-phosphate 5-kinase type 187, which produces phosphatidylinositol-4,5-bisphosphate

Methods Animal experiments The humanized Townes SCD transgenic (B6;129- Hba tm1(HBA)Tow Hbb tm2(HBG1,HBB*)Tow / Hbb tm3(HBG1,HBB)Tow /J) mouse 65 was obtained from Jackson Laboratories ( as breeders

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This is the least-studied route with no published research specific to nasal KPV