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[49] This was in response to an EU review, published in August 2017, which states that a plausible physiological explanation of these side effects "may be a reduction in plasma testosterone"

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In mitochondrial dysfunction in autism , these energy-producing systems dont run efficiently

Furthermore, the excessive accumulation of ROS not only disrupts the process of melanin synthesis, but also destabilises, synthesises and disrupts the circulation of lipids in melanocytes, resulting in damage to the mitochondrial electron transport chain and increased ROS production, creating a vicious cycle and destroying melanocytes [19]

USA 101 , 33813386 (2004)