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Petrovic I, Dobric I, Drvis P, et al

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S-glutathionylation of human glyceraldehyde-3-phosphate dehydrogenase and possible role of Cys152-Cys156 disulfide bridge in the active site of the protein

Theoretical concerns include subtle changes in gallbladder motility, pancreatic enzyme secretion, and gastric emptying that might not manifest as obvious symptoms but could have cumulative effects over years

However, this is still being studied, and patients with type 1 diabetes should only use semaglutide under strict medical supervision