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The activation of these kinases results in the phosphorylation of IRS1 on serine 307 resulting in inhibition of the insulin-stimulated tyrosine phosphorylation of IRS1 leading to inhibition of insulin signaling

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Apart from fisetin and sulforaphane mentioned above, taurine, an endogenous antioxidant, was shown to alleviate OS in diabetic rats by regulating the NF-B and Nrf2/HO-1 signaling cascades

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