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Conceptualizing GLP-1R as a dynamic architect of spatiotemporally encoded signalosomes opens new avenues for a deeper understanding of incretin biology with the potential for identification of novel GLP-1R effectors and the development of refined therapeutic strategies for metabolic disease

GLP-1 drugs (also called GLP-1 agonists) are medications originally marketed to treat diabetes

Monthly persistency erosion is steeper in obesity: Obesity GLP-1s drop to 32% persistence over 13 months, compared to 41% for diabetes

Ntika S, Thombare K, Aryapoor M, Kristinsson H, Bergsten P, Krizhanovskii C

At research-level dosages, studies have not reported extensive adverse effects

Side effect sensitivity: Nausea, bloating, constipationthese can be tough to handle