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Starting weight also matters

In a pilot study testing BSO/melphalan in 32 children with neuroblastoma, some tumors got smaller, however, 2 children died from decreased function of the kidneys combined with brain swelling

Advice for Developers : Early kinetic characterization (KI, kinact) and mechanistic modeling help predict clinical DDI risk and guide structural optimization or dosing strategies

It is indicated when other medications, such as metformin, are insufficient for glycemic control

Histidine has a chemical side chain that forms a stable bond with copper ions, allowing the peptide to carry copper into cells without it becoming toxic or reactive in the process

Its a waste of a perfectly good peptide