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The role of tirzepatide, dual GIP and GLP-1 receptor agonist, in the management of type 2 diabetes: the SURPASS clinical trials

"Smaller players will likely need to demonstrate either superior tolerability, novel indication-specific efficacy, meaningfully different dosing convenience, or combination strategies that address limitations of current agents, particularly muscle loss, rather than simply competing on weight-loss magnitude alone," says Nadolsky

"The field is also exploring migraine, intracranial hypertension, inflammatory bowel disease, psoriasis, and rheumatoid arthritis, all out of my wheelhouse," he says

Key clinical wins : In 2024, Lilly announced new clinical trial results (e.g., further cardiovascular outcome benefits with tirzepatide), which have bolstered prescriber confidence

In 2021, the annual sales of the drug surpassed $10 billion for the first time, reaching $10.76 billion

Key players include: Novo Nordisk : The market leader with semaglutide (Ozempic/Wegovy) and liraglutide (Saxenda/Victoza)