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Endothelial dysfunction, dysregulation of ER stress and autophagy pathways, mitochondrial toxicity, calcium imbalance, and several other side effects have also been observed in kidneys, the gut, major arteries, liver, and other organs (Apostolova et al

announced Monday that it's rolling out injectable weight-loss drugs that cost a fraction of the price of competitors Wegovy and Ozempic

"Centenarians display plasma MOTS-c concentrations significantly higher than age-matched peers, a pattern that closely resembles levels found in individuals decades younger suggesting preserved mitochondrial signaling as a hallmark of exceptional longevity." The connection to cellular senescence deserves further attention here

More than 1000 unique species of bacteria make up the gut microbiome

The same active ingredient powers Wegovy, which received FDA approval specifically for obesity treatment in 2021

A., & Rizzo, M