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22 However, epidemiological and clinical studies have linked hyperuricemia to the development of various conditions, including chronic kidney disease, fatty liver, metabolic syndrome, hypertension, insulin resistance, obesity, type 2 diabetes, and cardiovascular and cerebrovascular disorders

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Brooks AM, Walker N, Aldibbiat A et al (2013) Attainment of metabolic goals in the integrated UK islet transplant program with locally isolated and transported preparations

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But melanotan a synthetic hormone-like drug which increases melanin production in skin cells to deepen skin pigment has actually been linked to increased risk of skin cancer and other side effects including kidney failure