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1995, Clinical aspects of growth hormone deficiency in adults

3.2.2 TGF--induced mitochondrial ROS production Mitochondria are the primary intracellular source of ROS, and TGF-1 markedly enhances their production across multiple cell types, contributing to apoptosis, senescence, epithelialmesenchymal transition (EMT), and fibrotic gene expression associated with myofibroblast differentiation [58]

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alternate supplement formulations of vitamin B 12 , such as methylcobalamin and hydroxycobalamin, have been suggested for this patient population

BPC-157 decreased TNF-, IL-6, and IL-1 levels in tissue samples