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Two recent studies found that S- and RBD-specific immunoglobulin G (IgG) antibodies in patients with COVID-19 have lower levels of fucosylation within their Fc domains 26,27 a phenotype linked to higher affinity for FcRIIIa, an activating Fc receptor (FcR) that mediates antibody-dependent cellular cytotoxicity

181 Similarly, sclareol significantly decreased levels of IL-1, TNF-, and IL-6 in Crohns disease models while upregulating tight junction proteins and preserving mucosal structure, indicating immunomodulatory and barrier-stabilizing roles

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Acknowledgments We acknowledge Dr

Hollis, F., Kanellopoulos, A