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This is especially promising for CNS disorders

Computational Identification of Genetic Biomarkers for Neurodegenerative Diseases via Machine Learning, Lalit Varada, Isoif Vaisman 62

Since the response is dose-sensitive and even biphasic, careful studies test a spread of concentrations across several orders of magnitude rather than betting on one number

Am J Pathol 163(5):18011815 St Croix B et al (2000) Genes expressed in human tumor endothelium

Handling Bleeding Bleeding will be the most common after-effect, and most of it will happen in the initial two days