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cmh-2022-0330-Supplementary-4.pdf Supplementary Material 5

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Sodium-glucose co-transporters are responsible for 97% of glucose reabsorption6 and their inhibition lowers blood glucose by increasing renal glucose excretion.4 , 5 Using SGLT-2 inhibitors increases the risk of DKA6 , 7 by decreasing daily carbohydrate availability by 20%45%,9 lowering endogenous insulin production and stimulating lipolysis that leads to ketogenesis.6 Patients who also receive insulin may decrease insulin doses in response to lower blood glucose patterns, leading to insulin deficiency

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The sensitivity and specificity at the cut-off points for -GluCys, LA, and D-lactate were 88.00 and 81.48%, 80.00 and 77.78%, and 88.00 and 77.78%, respectively