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Absorption Injected free B12 diffuses through the extracellular fluid into nearby capillaries, enters the bloodstream and binds to TCII (transcobalamin II)
Metabolic pathway requiring 5-deoxyadenosylcobalamin The figure illustrates the metabolic pathway for the vitamin B 12 -dependent enzyme L-methylmalonyl-CoA mutase, which converts L-methylmalonyl-CoA into succinyl-CoA for entry into the citric acid cycle
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B12 is often cited as a vitamin found naturally only in meat, dairy and other animal foods
When to Seek Medical Advice About B12 and Joint Symptoms Knowing when to contact your GP or healthcare provider regarding joint symptoms in the context of B12 supplementation is essential for ensuring appropriate investigation and management
The refrigerator is ideal because it provides both temperature control and darkness
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