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Finally, knockdown of Gln transporters (SLC38A1 and SLC1A5) or pharmacological inhibition of SLC1A5 also significantly blocked cysteine starvation-mediated ferroptosis [85, 86]

Treatment typically begins with 2.5 mg once weekly for 4 weeks, then increases in 2.5 mg increments every 4 weeks as tolerated to the target dose

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Another interesting MERCS function is related to lipid synthesis

M., Weinborn, M., Verdile, G., Sohrabi, H