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Prompt identification and withdrawal of the suspected offending agent are the crucial first steps in management

REST directly binds to the promoter region of glutamate-cysteine ligase (GCLM), inhibits the synthesis of GSH through transcriptional inhibition of GCLM expression, and induces ferroptosis

To view a copy of this licence, visit About this article Cite this article Mahani, M., Fallahi Nezhad, F., Khakbaz, F

A structural model of the interaction suggests that the active molecule is a hydrolyzed form of PL (hPL) which forms a complex with GSH in the enzyme active site

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