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The participation of ThDP in cellular folate absorption (Figure 2A) endows SLC44A4 with a physiologically relevant function to return ThDP that is extruded in exchange for folate, back to the cell (Figure 2A)

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Even so, having a more typical MC1R genotype suggests this receptor is less likely to be a major limiting factor within the broader melanocortin network

Qiu et al., 2017)

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