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In conclusion, these findings demonstrate that oral l-carnitine could be conferring an increased risk to develop atherosclerosis over years of therapy due to chronic and extreme elevations in TMAO

Together, these results reinforce the concept that AKT1 acts as a key integrator of metabolic stress and transcriptional reprogramming in lipedema, orchestrating alterations in energy production, amino acid metabolism, and antioxidant defence

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10.1016/j.jtemb.2020.126570 J Trace Elem Med Biol

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Intermittent fasting increases fat oxidation and promotes metabolic flexibility in lean mice but not obese type 2 diabetic mice