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This uncertainty can delay wider adoption and reimbursement approvals, especially for off-label or preventive use

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A Herxheimer reaction can temporarily intensify symptoms such as fatigue, pain, brain fog, dizziness, or flu-like illness after treatment begins

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As an adaptor protein, Keap1 senses intracellular induction signals through its multiple reactive cysteine residues, thereby mediating Nrf2 degradation (Dinkova-Kostova et al., 2017)

People who are fatigued or stressed become intoxicated more quickly than people who are rested and relaxed