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Common gastrointestinal side effects occur in the majority of patients and include nausea (reported in 20-50% depending on the agent and dose), vomiting, diarrhea, constipation, and abdominal pain

A new option for the starting dosing regime of Lequembi has been approved

Acknowledgements The National Natural Science Foundation of China (82073144, J.W.), the Health Commission of Zhejiang Province (JBZX-202004, J.W.), the Huadong Medicine Joint Funds of the Zhejiang Provincial Natural Science Foundation of China (LHDMD22H310005, J.W.)

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However, more research is required to assess its therapeutic potential in advanced illness and clarify the specific mechanisms of its hepatoprotective benefits

Choose cooler hours for activity : Exercise early morning or evening when temperatures are lower and humidity is less intense