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This necessitates the development of next-generation systems that can provide a controlled, sustained, and targeted antimicrobial activity

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After immunization for 15 days (day 15), the arthritic mice in the four AIA groups were intraarticularly injected with PBS (20 L) or PBS containing MnTCPP + monochloride (10 mg/kg), Zn(NO 3 ) 2 (10 mg/kg), or ZMTP nanosheets (10 mg/kg) at the pathological sites of arthritis

Evidence From Preclinical & Clinical Studies A) Skin permeation & bioavailability In-vitro penetration: A Franz-cell model showed human skin penetration of GHK-Cu in vitro, supporting the feasibility of topical delivery (PMC)

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DOI: 10.1113/jphysiol.2013.255364