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Histopathological studies have demonstrated increased numbers of CD3 + T lymphocytes, CD68 + macrophages, and mast cells in the colonic mucosa and muscularis of chronic constipation patients (Trnblom et al., 2002)

In high-income countries, diabetes is one of the leading causes of cardiovascular disease, blindness, kidney failure, and lower limb amputation

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Individual responses vary significantly based on genetic factors, body composition, and baseline metabolic function