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SIRT1 was involved in TNF--promoted osteogenic differentiation of human DPSCs through Wnt/-catenin signal

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51 One significant challenge is the high rate of gastrointestinal adverse events associated with these compounds, which may be related to their pharmacokinetic properties and direct gastrointestinal irritation

[1] [2] Similarly, the SCALE trials for liraglutide 3mg (Saxenda) documented fatigue as a common adverse reaction