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Basically, cyanocobalamin needs to be broken down to cobalamin and cyanide in order to convert to the active form of B12, and some researchers have concerns about the effects of cyanide accumulation in the body with long-term use of cyanocobalamin but the jurys still out on whether thats a cause for concern

Preclinical Research Is Not Clinical Proof Animal and laboratory studies can help researchers form hypotheses, examine biological pathways and decide whether further investigation is justified

What evidence does not show: Uncontrolled or pathological collagen overproduction

Redox-active small molecules (Methylene Blue): investigated for mitochondrial electron-transport-chain interaction and cellular oxidative-stress models

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In the GHK-Cu formulation, it is specifically used to promote collagen and elastin synthesis, wound healing, reduction of inflammation, and cell renewal