Well-tolerated in preclinical models at effective dosages
Bacterial infection: Bacterial nail pigmentation, which is most commonly due to Pseudomonas aeruginosa , Klebsiella and Proteus spp ., exhibits a greenish or grayish hue and the discoloration is often confined to the lateral edge of the nail[110]
HSP70 binds to specific non-coding RNA and regulates human RNA polymerase III
Particularly, manganese dioxide (MnO 2 ) nanosheets are usually selected as GSH biosensors, owing to their excellent colloidal stability, absorption capability, redox chemistry and biocompatibility 22,23,24
This conclusion is supported by Gatto et al
however, this hypothesis remains to be confirmed in prospective studies specifically targeting early PsA populations.However, emerging data also underscore the complexity of this therapeutic hypothesis