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The reference lists of each included study were also used to identify any additional studies

In addition to blunted monoaminergic neurotransmission, it was also shown that deficiency in neurotrophic factor effects, disturbances in neurogenesis and synaptogenesis, chronic neuroinflammatory processes, and dysregulation of the hypothalamicpituitaryadrenal (HPA) axis can largely contribute to the manifestation of depressive symptoms in patients [3,4,5]

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In conclusion, we have developed SVM and random forest based methods for discriminating HCV genotypes and subtypes

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