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Safety, pharmacokinetic, and pharmacodynamic phase I dose-escalation trial of PF-00562271, an inhibitor of focal adhesion kinase, in advanced solid tumors

Thereby, this pitfall (i.e., the more carriers, the less own peptide activity) is commonly not considered (Saghazadeh et al., 2018

And the difference between those doses is the difference between observable results at 12 weeks versus no measurable change

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Caputi S, Trubiani O, Sinjari B, Trofimova S, Diomede F, Linkova N, et al