10.1016/s0893-133x(01)00229-9 46 HsiehJ
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Interestingly, DFMC collapsed rapidly after being endocytosed in tumor cells, displaying a noticeably responsive-released behavior in the presence of GSH and an acidic microenvironment (GSH = 10 mM, pH = 6.5) (Figure 4D)
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The transmembrane rather than paracellular transport of lipophilic compounds was supported by the demonstration of an inverse association between lipid/water partition coefficient and increased transport rate following calcium chelation, i.e., disrupting intercellular junctions increased the transport of hydrophilic but not of lipophilic small organic molecules [31]