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In cultured cardiomyocytes, DOX concentrates in mitochondria, increasing mitochondrial iron deposition and ROS levels, and dexrazoxane has demonstrated efficacy in reversing DOX-induced cardiomyopathy by lowering mitochondrial iron levels

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For general safety background, refer to CDC Safe Injection Practices

Liver regeneration is severely impaired when macrophages are depleted in response to acute liver injury, such as PHx, acetaminophen overdose, acute carbon tetrachloride (CCl 4 ) or chronic liver injury

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