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survodutide is earlier in its Phase 3 program, with timelines that depend on its obesity and MASH trials reading out

Conversely, despite favourable outcomes of multiple studies using abbreviated DAPT of 36 months (including new studies below), this strategy was given a IIB rating based on potential generalisability of trial data to real-world practice

Fremaux, J

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The mice showed pronounced increases in body weight, food intake, and levels of liver injury markers, such as plasma alanine transaminase (ALT), aspartate aminotransferase (AST), tissue inhibitor of metalloproteinase-1 (TIMP-1), triglyceride (TG), cholesterol, and low-density lipoprotein cholesterol (LDL-C), compared to normal mice

[7] In some cases muscle tissue in the lip underneath the scar is affected and might require reconstructive surgery