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The success of these therapies has paved the way for the development of next-generation treatments, including multi-agonist molecules like Tirzepatide (Mounjaro/Zepbound) or Retatrutide (LY3437943) that simultaneously target several metabolic receptors to achieve improved metabolic outcomes in obese or diabetic patients [3,6]

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Preliminary studies show promising reductions in body weight, apneahypopnea index (AHI), and systemic inflammation, although long-term trials remain warranted

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How it works: MK-677 mimics ghrelin, the "hunger hormone." When ghrelin signals rise, your pituitary releases more growth hormone