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It's the reason centella-based products have a strong reputation for repairing and calming skin, along with its sibling compound Madecassoside

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It also increases the risk of heart diseases such as heart attack and stroke

Hematologic Toxicity: Monitor hemoglobin or hematocrit in patients with any signs or symptoms of anemia (5.12, 7) Adverse Reactions/Side Effects The most frequent adverse events were headache (15%), followed by dyspepsia (14%), and flu syndrome (10%)

Tier 1: BMI 35 or higher BMI 35 or higher, no other conditions required