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Together, the three B vitamins support haematological, neurological, and metabolic health, and combined deficiency is particularly common in older adults, vegetarians and vegans, those on long-term acid-suppressing medication, and people with malabsorption

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Other indications include malabsorption disorders (such as Crohn's disease or coeliac disease), following gastric surgery, strict vegan diets without supplementation, and certain medications that interfere with B12 absorption