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Most of the studies on androgen binding in androgen insensitivity syndromes36 have been carried out in primary cultures of human skin fibroblasts.37 Two different size forms of AR have been detected in these cells and other cells and tissues37 and designated A (87 kDa) and B (110 kDa)

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Researchers choose DES(1-3) when they need a short-acting, potent IGF-1R stimulus for acute signaling studies, and IGF-1 LR3 when sustained receptor activation or reduced dosing frequency is required