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There are a variety of unimolecular dual GLP-1/glucagon receptor (GLP-1/GCGR) agonists in clinical development, based on the native peptides (glucagon,GLP-1, oxyntomodulin, exendin), including cotadutide (MEDI0382) [23, 24], SAR425899 [25], pegamodutide (OPK88003), and efinopegdutide (HM12525A)

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