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Baseline ALT and AST before starting either agent is reasonable clinical practice, with repeat testing at 3 months if any hepatic risk factors exist

For compound treatment, the medium was replaced by 90% of Williams E Medium supplemented with 12.5% HepaRG preinduction and toxicity medium supplement, 0.6% HepaRG induction medium supplement (Lonza, catalog: MHIND), and 25 U/mL penicillin-25 g/mL streptomycin

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Metabolic and Redox Regulation of Neural Stem Cells Neural Stem Cell Basics The majority of neural stem cells (NSCs) that can undergo adult neurogenesis in the brain are present in either the subventricular zone (SVZ) adjacent to the lateral ventricles, or the subgranular zone (SGZ) of the hippocampal dentate gyrus (DG) (Figure 1)

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