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PMID: 25679448

2021YFA1100500 (H.Y.)

T.PhadnisV

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The upregulation of these cytokines will activate and promote an inflammatory cascade, leading to various signs and symptoms

Recent studies indicate that metformin strengthens the protective function of the intestinal mucosal barrier by increasing the abundance of Akkermansia muciniphila and the number of goblet cells, resulting in a thicker mucus layer that reduces inflammation in the intestines (Shin et al., 2014