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If you develop NAION while on this medication, it will likely result in permanent visual impairment." Additional NAION-related Wegovy lawsuits were combined in November 2025 into a multicounty litigation (MCL) in New Jersey state court

The FNDC5 cleavage and secretion process itself remains incompletely understood: the efficiency of irisin shedding in humans appears lower than in rodents, partly explaining why rodent exercise phenotypes driven by irisin overexpression have been difficult to reproduce cleanly in human studies

Published April 14, 2025.

10.1016/j.cell.2016.05.011 [DOI] [PMC free article] [PubMed] [Google Scholar] Xiong, Y

Amidon GL, Lennerns H, Shah VP, Crison JR

How Does Wegovy Cause Blood Clots