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Glucagon-like peptide 1 therapy: from discovery to type 2 diabetes and beyond

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In patients with type 2 diabetes and rheumatoid arthritis, retrospective analyses suggest that GLP-1 receptor agonists may provide glycemic and weight benefits comparable to those seen in the general diabetes population, without apparent increases in rheumatoid arthritis flares or complications, though these observations are based on small samples

In trials, the incidence of acute pancreatitis was 0.2% in both tirzepatide- and placebo-treated patients