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(Wilding JPH et al., NEJM 2021) The SELECT trial (N=17,604), published in the New England Journal of Medicine in 2023, showed a 20% reduction in major adverse cardiovascular events (MACE) with semaglutide 2.4 mg in adults with existing cardiovascular disease and overweight or obesity but without diabetes (Lincoff AM et al., NEJM 2023)
Importantly, each hallmark was defined not only by its association with aging, but also by experimental evidence suggesting that modifying these mechanisms could influence lifespan or healthspan
Semaglutide, 2
Similarly, a meta-analysis conducted in the same year aimed to evaluate the impact of obesity on LVAD-related outcomes [70]
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