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These medications also delay gastric emptying, meaning food stays in your stomach longer, creating a prolonged feeling of fullness

Critically, the glucagon component in cotadutide does not show this catabolic effect, given that the balance of GCGR and GLP-1R activity within cotadutide has been optimized to achieve the specific benefits of glucagon-induced inhibition of hepatic lipogenesis, while still allowing for metabolic switching in response to glycemic status 13

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Special population dosing considerations may apply to certain patient groups, though specific recommendations for the oral disintegrating tablet formulation may differ from those established for injectable tirzepatide

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Reflux or regurgitation of gastric contents can create a sour, bitter, or unpleasant taste in the mouth