Despite the demonstrated efficacy of GLP-1 receptor agonists in reducing weight and improving metabolic control in adolescents, their long-term molecular and systemic consequences remain poorly understood
PMID: 22 PallagiPGrgMPappNMadcsyTVargaCrulTet al
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It acts as an agonist at the growth hormone secretagogue receptor (GHSR/ghrelin receptor), stimulating GH release from anterior pituitary somatotrophs
[DOI] [PubMed] [Google Scholar] 24.Feeney DA, Anderson KL, Ziegler LE
Peptide drug treatment Mice were treated via subcutaneous (s.c.) injection at the indicated doses with either long-acting acyl-GIP (100 nmol kg 1 s.c.), LIRA (100 nmol kg 1 s.c.) or an acylated peptide GIPR antagonist ([N-Ac,L14,R18,E21]hGIP(531)-K11(E-C16)) (1500 nmol kg 1 s.c.)