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Notably, basal levels of circulating GLP-1 were not different in HFHC-fed Glp1r Tie2/ mice, and oral administration of glucose or olive oil induced plasma levels of total GLP-1 to a similar extent in both Glp1r Tie2+/+ and Glp1r Tie2/ mice (Supplemental Figure 3)

It can also reverse the harmful effects of a high-fat diet on liver metabolic pathways and related regulators, such as ACOX, SCAP, SREBF, PPARGC1B, and INSR (91)

Beta-cell function improvements, if they occurred during treatment, can persist for months beyond cessation

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Lin Y, Yang R yu, Li J, et al

Accessed 01/08/2026 at Wharton, S., Freitas, P., Hjelmesth, J., Kabisch, M., Kandler, K., Lingvay, I., Quiroga, M., Rosenstock, J., Garvey, W