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This peptide hormone is synthesized predominantly by L cells in the intestine and neurons residing in the nucleus of the solitary tract (NTS), located within the hindbrain [47]

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A randomized, placebo-controlled study in the Journal of Clinical Endocrinology & Metabolism found that a single injection produced 2 to 10 fold GH increases for 6+ days and 1.5 to 3 fold IGF-1 increases for 9 to 11 days in healthy adults Combined effect: Ipamorelin triggers immediate GH release, while CJC-1295 sustains it