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The antioxidant effect of BBR depends on Nrf2-ARE pathway, and the process involves up regulation of HO-1, SOD and NQO-1 protein expression, and the protective effect is obviously reduced after Nrf2 gene is knocked out

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However, some parts of GRP and SFN are not metabolized by gut microbiota and are excreted intact with urine or feces

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[DOI] [PubMed] [Google Scholar] 67.El-Khoueiry AB, Sarantopoulos J, OBryant CL, Ciom-bor KK, Xu H, OGorman M, et al