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For employers operating on tight benefit budgets, thats an untenable increase to absorb especially when utilization consistently came in higher than projected. In conversations documented by the Kaiser Family Foundation and Peterson Center on Healthcare, employers described trying multiple cost-management strategies step therapy requirements, prior authorization, weight-loss program prerequisites before ultimately concluding that no guardrail was controlling the spend fast enough. Importantly, the law doesnt require employers to offer GLP-1 coverage

Compounding pharmacies in some countries have started producing GLP-1 drugs like semaglutide during shortages

The metabolic environment that caused the problem in the first place is still intact

Notably, a dose-dependent increase in heart rate, peaking at 24 weeks, subsequently decreased [19]

[1] [3] The precise mechanism underlying this heart rate elevation has not been fully established

Rizzo, M., et al