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Participants achieved 13.4% weight loss with 15mg tirzepatide versus 2.5% with placebo over 72 weeks

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Tirzepatide, compared to both GLP-1 and NNC0090-2746, shows biased signaling at GLP-1R, favoring cAMP response over -arrestin recruitment, which leads to low efficacy for GLP-1R internalization (108110)

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