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Free radicals and antioxidants in normal physiological functions and human disease

Dosing paradigms, route of administration, and exposure considerations Published in vivo experiments commonly use intraperitoneal (i.p.) administration at 50 mg/kg twice daily for 1228 days in adult male C57BL/6J or ob/ob mice, with cohorts kept at thermoneutrality and studied by indirect calorimetry (CLAMS) and body-composition analyses

doi:10.1186/s12967-020-02471-0

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According to NICE Clinical Knowledge Summaries, once B12 deficiency is adequately treated and symptoms resolve, routine monitoring of serum B12 levels is generally unnecessary, as clinical response is the primary indicator of treatment effectiveness

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